You sign up log in groups lung cancer survivors support community home new recommended discussions journals members about sign up all active recommended topics start a discussion rrm1 expression predictive for vinorelbine efficacy by bifnreg · yesterday at 9:18 pm · 0 replies in non-small cell lung cancer - stage iv 0 recommend recommended processing...    follow replies stop following processing...    problem    options options: print shared with the public just came across this in md linx. Probably old news but thought i'd pass it along anyway. Best wishes to all, mel predictive impact of rrm1 protein expression on vinorelbine efficacy in nsclc patients randomly assigned in a chemotherapy phase iii trial annals of oncology, 10/08/2012 clinical article vilmar ac et al. – the authors explored the predictive role of ribonucleotide reductase subunit m (rrm1) in advanced non–small–cell lung cancer (nsclc). Rrm1 protein expression was without any predictive impact in patients treated with cisplatin, paclitaxel and gemcitabine. Surprisingly, the predictive power was demonstrated in the cisplatin and vinorelbine arm and may suggest that rrm1 is involved in vinorelbine sensitivity warranting further research. Methods •a total of 443 patients were randomly assigned to regimen a [paclitaxel (taxol) and cisplatin with gemcitabine] or regimen b (cisplatin and vinorelbine). •immunohistochemical evaluation of rrm1 was correlated to clinical end-points. Results •a total of 261 (58. 9%) patients had representative tissue samples for rrm1 evaluation. •disease control rate, progression-free survival (pfs) and overall survival (os) were substantially improved in patients with rrm-negative (neg) tumors receiving regimen b when compared with patients with rrm-positive (pos) tumors (68. 8% versus 31. 2%, p=0. 046, 6. 90months versus 3. 93months, p=0. 000 and 11. 57months versus 7. 4months, p=0. 002, respectively). •interaction analysis between rrm1-neg status and adenocarcinomas yielded a hazard ratio (hr) of 0. 36 for death (p=0. 000). Explore topics in this post explore topics in this post: cancer chemotherapy lung cancer paclitaxel taxol reply please sign in to reply don't have an inspire account? Join now! E-mail: password: forgot password? Keep me signed in checking this option will keep you signed in on this computer until you sign yourself out. Do not check this option if you are on a public computer. Things you can do start a discussion post a journal entry meet others like you update your profile discussion topics non-small cell lung cancer - general non-small cell lung cancer - stage i non-small cell lung cancer - stage ii non-small cell lung cancer - stage iii non-small cell lung cancer - stage iv small cell lung cancer -. viagra without a doctor prescription cheapest canadian pharmacy for viagra buy viagra viagra for sale buy cheap viagra cheap viagra online buy viagra viagra online cheap generic viagra viagra online  
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